Christian M. Beausejour

This study shows senescent fibroblasts in humanized mouse models promote tumor progression by inducing neutrophil extracellular traps (NETs) that impair immune responses.

The paper shows senescent human fibroblasts increase FasL expression, leading to T and NK cell apoptosis and impaired tumor immune response in humanized models.

This paper describes engineered liver tissue that reverses acute liver failure in mice without immunosuppression, demonstrating potential for clinical translation.