This paper introduces an mRNA-LNP method to assess immune effector cell-mediated cytotoxicity, showing it is rapid, consistent, and compatible with diverse tumor models.

Frontiers in Immunology · May 11, 2026Peer-reviewedImmunology

Enhanced lentiviral gene delivery to mammalian cells via paired cell surface and viral envelope engineering

Ryan Tannir, Letitia Chan, Tomasz M. Grzywa, Orlando D. Arevalo, Alexandra Neeser, Sara Kahn, Austin Cozzone, Arjun Ramamurthi, Lauren K. Olenick, Nicola J. Mason, Xue‐Yuan Liu, Leyuan Ma

This paper improves lentiviral gene delivery to mammalian cells by engineering virus-envelope and cell-surface interactions using FITC labeling and chimeric envelopes.

Molecular Therapy Advances · Jan 3, 2026Peer-reviewedBioengineering

Mechanism of biomimetic virus-like nanoparticles in triggering immune response elucidated by proteomics

Jiajia Wang, Ahmed B. Montaser, Minna Sivonen, Henri Leinonen, Lucas Nygård, Tuure T. Kinnunen, Sini Pitkänen, Anna-Liisa Levonen-Harju, Enkhzaya Batnasan, Leena Latonen, Jussi Hepojoki, Leyuan Ma, Vesa‐Pekka Lehto, Wujun Xu

This study investigates how spike structures on virus-like nanoparticles enhance immune responses in macrophages through proteomic analysis of signaling pathways.

Colloids and Surfaces B Biointerfaces · Dec 2, 2025Peer-reviewedImmunology

Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells

Tomasz M. Grzywa, Alexandra Neeser, Ranjani Ramasubramanian, Anna M. Romanov, Ryan Tannir, Naveen K. Mehta, Benjamin James Cossette, Duncan M. Morgan, Beatriz Goncalves, Ina Sukaj, Elisa Bergaggio, Stephan Kadauke, Regina M. Myers, Luca Paruzzo, Guido Ghilardi, , Darrell J. Irvine

This study develops a method to generate optimized peptide ligands for CAR-T cell restimulation, demonstrating enhanced expansion and memory development in preclinical models.

Nature Biomedical Engineering · Aug 25, 2025Peer-reviewedBioengineering