Nikolaos Barkas

Niche signals regulate continuous transcriptional states in hematopoietic stem cells

The paper identifies six HSC states and shows niche perturbations induce rapid transitions between them, revealing HSC-specific molecular signatures and chromatin features related to regenerative potential.

Single cell transcriptomics of primate sensory neurons identifies cell types associated with human chronic pain

The paper identifies primate sensory neuron types associated with human chronic pain using transcriptomics and maps human pain heritability to these neuronal types.

Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing

The paper investigates how intragenic CpG islands (iCGIs) influence host gene pre-mRNA processing through transcriptional activity, showing a correlation between iCGI transcription and premature termination of host gene transcripts.

Unraveling intratumoral heterogeneity through high-sensitivity single-cell mutational analysis and parallel RNA-sequencing

This study introduces TARGET-seq, a method that simultaneously detects mutations and performs RNA-sequencing in single cells, revealing transcriptional and genetic tumor heterogeneity in myeloproliferative neoplasm cells.

Wiring together large single-cell RNA-seq sample collections

The paper introduces Conos, a method for joint clustering of large single-cell RNA-seq datasets to identify recurrent cell subpopulations across multiple samples.