Author

Nikolaos Sousos

John Radcliffe HospitalORCID 0000-0002-9100-2954Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. Marieke OudelaariD· 1 shared Adam J. MeadiD· 1 shared Alba Rodríguez-MeiraiD· 1 shared Alice GiustacchiniiD· 1 shared Andrew Smith· 1 shared Angela D. HambliniD· 1 shared Barbara XellaiD· 1 shared Benjamin J. Povinelli· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

A. Marieke OudelaarORCID

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2 papers

Recent·Most cited

Multipartite super-enhancers function in an orientation-dependent manner

Mira T. Kassouf, Helena S. Francis, Matthew E. Gosden, Maria Suciu, Damien J. Downes, Caroline L. Harrold, Martin Larke, A. Marieke Oudelaar, Lucy Cornell, Joseph Blayney, Jelena M. Telenius, Barbara Xella, Yuki Shen, Nikolaos Sousos, Jacqueline A. Sharpe, , Douglas R. Higgs

The paper shows that super-enhancers function directionally and orientation-dependently, unlike regular enhancers, by analyzing the β-globin super-enhancer.

bioRxiv · Jul 14, 2022 · PreprintMolecular Biology

Unraveling intratumoral heterogeneity through high-sensitivity single-cell mutational analysis and parallel RNA-sequencing

Alba Rodríguez-Meira, Gemma Buck, Sally‐Ann Clark, Benjamin J. Povinelli, Verónica Alcolea, Eleni Louka, Simon J. McGowan, Angela D. Hamblin, Nikolaos Sousos, Nikolaos Barkas, Alice Giustacchini, Bethan Psaila, Sten Eirik W. Jacobsen, Supat Thongjuea, Adam J. Mead

This study introduces TARGET-seq, a method that simultaneously detects mutations and performs RNA-sequencing in single cells, revealing transcriptional and genetic tumor heterogeneity in myeloproliferative neoplasm cells.

Molecular Cell · Feb 11, 2019Peer-reviewedGenomics