Toxoplasma induced cytokine release syndrome is critically dependent on the expression of pore-forming Perforin-Like Protein-1
Beth Gregg, Alfredo J. Guerra, Stephen Raverty, Aline Sardinha-Silva, Björn F.C. Kafsack, Tracey L. Schultz, Stephen J. Gurczynski, Bethany B. Moore, Vernon B Carruthers, Michael E. Grigg
This study shows that Toxoplasma gondii's PLP1 protein drives cytokine release syndrome by inducing dysregulated immune responses, leading to lethal inflammation during acute infection.
bioRxiv · Mar 17, 2025 · PreprintMicrobiology