Michael E. Grigg

This paper develops a live-attenuated Toxoplasma vaccine by knocking out DGAT1, showing it provides long-term protection against both acute and chronic toxoplasmosis.

The paper develops and validates a set of 100,000 RNA baits (CryptoCap_100k) to enrich Cryptosporidium DNA from clinical and environmental samples, improving read mapping, coverage, and variant analysis while reducing costs.

The paper investigates how TRIM5α restricts orthoflavivirus replication and identifies a mutation in POWV's NS3 gene that allows it to evade TRIM5α inhibition.

This study shows Giardia intestinalis induces a Type 2 immune response that reduces inflammation in the gut, protecting against inflammatory bowel-like diseases.

This study shows that Toxoplasma gondii's PLP1 protein drives cytokine release syndrome by inducing dysregulated immune responses, leading to lethal inflammation during acute infection.

This study develops PCR and sequencing methods to rapidly detect and differentiate Leishmania species causing human infections.

This study shows ESCRT-I and ALIX form helical filaments in vivo, serving as structural scaffolds and ESCRT-III assembly templates for membrane scission and viral budding.

This study uses CES-Seq to sequence Cryptosporidium genomes directly from clinical samples, revealing genetic diversity and enabling phylogenomic analysis and GWAS.

The paper identifies ROP33 as a murine virulence gene in Type X Toxoplasma gondii strains isolated from southern sea otters, showing differential pathogenicity across hosts.

POPSICLE improves genotype-phenotype predictions by integrating population genetics and GWAS methods using whole genome sequencing data.