Author

Aline Sardinha-Silva

National Institutes of HealthORCID 0000-0002-2427-9515Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Beth Gregg· 2 shared Michael E. GriggiD· 2 shared Alfredo J. GuerraiD· 1 shared Bethany B. MooreiD· 1 shared Björn F.C. KafsackiD· 1 shared Camila H. CoelhoiD· 1 shared Eliza V.C. Alves‐FerreiraiD· 1 shared Erick T. TjhiniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

Beth Gregg

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ImmunologyNature MicrobiologyPeer-reviewedJul 8, 2025

Giardia intestinalis reshapes mucosal immunity toward a Type 2 response that attenuates inflammatory bowel-like diseases

Aline Sardinha-Silva, Pedro Henrique Gazzinelli-Guimarães, Oluwaremilekun Grace Ajakaye…·Michael E. Grigg

This study shows Giardia intestinalis induces a Type 2 immune response that reduces inflammation in the gut, protecting against inflammatory bowel-like diseases.

29 citationstop 1%

humanexperimental assay

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MicrobiologybioRxivPreprintMar 17, 2025

Toxoplasma induced cytokine release syndrome is critically dependent on the expression of pore-forming Perforin-Like Protein-1

Beth Gregg, Alfredo J. Guerra, Stephen Raverty…·Michael E. Grigg

This study shows that Toxoplasma gondii's PLP1 protein drives cytokine release syndrome by inducing dysregulated immune responses, leading to lethal inflammation during acute infection.

2 citations

mouseproteomics

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