The sodium leak channel NALCN is regulated by neuronal SNARE complex proteins
Samuel George Usher, Estelle Toulmé, Roberta Florea, Stanislau Yatskevich, Christine C. Jao, Luuk Robin Hoegen Dijkhof, Janne M. Colding, Prajakta Joshi, Inna Zilberleyb, Thorsten Trimbuch, Bettina Brokowski, Alexander S. Hauser, Alexander Leitner, Christian Rosenmund, Marc Kschonsak, Stephan Alexander Pless
The paper shows that SNARE complex proteins inhibit NALCN channel activity and that reducing NALCN currents promotes cell survival in syntaxin-depleted cells.
Science Advances · Mar 14, 2025Peer-reviewedNeuroscience