Christian Rosenmund

This paper shows that presynaptic filopodia, driven by activity, calcium, and actin, physically modulate membrane mechanics to enhance synchronous neurotransmission and contribute to seizure generation.

This study identifies Nup153's role in repressing neuronal genes through HDAC1-mediated epigenetic regulation, influencing chromatin states and neuronal responsiveness.

This study visualizes synaptic vesicle fusion dynamics in mouse hippocampal neurons using cryo-electron tomography and simulations, revealing five fusion intermediates and a model of calcium-triggered fusion.

This study shows that mTORC1-dependent translation in layer 5b neurons is essential for memory consolidation through activity-dependent plasticity.

This study identifies Piccolo's role in astrocytic ECM secretion, showing its impact on synapse formation and neuronal network activity in PCH3.

The paper shows that SNARE complex proteins inhibit NALCN channel activity and that reducing NALCN currents promotes cell survival in syntaxin-depleted cells.

This paper proposes a lever hypothesis for Synaptotagmin-1 action in neurotransmitter release, suggesting it pulls SNARE complexes to facilitate membrane fusion.

This study uses cryo-electron tomography to describe the molecular architecture and structural heterogeneity of individual synaptic vesicles in mouse brains and cultured neurons.

This study identifies two distinct regions in the synaptotagmin-1/SNARE complex interface that mediate different functions in neurotransmitter release and shows that Ca2+ triggers a rearrangement of this interface.

The paper shows that Ire1α regulates mRNA translation rates, which control the identity and polarity of upper layer cortical neurons through eIF4A1 and eEF-2.

The paper introduces ROInet-seq, a method to map brain-wide monosynaptic connectivity using barcoded rabies virus and RNA-sequencing, revealing preserved regional network motifs in cortical areas.

This study investigates the role of the C-terminal half of the SNARE domain of Syntaxin-1A in synaptic vesicle stability and neurotransmitter release regulation.

The paper identifies specific amino acid residues in the complexin N-terminus that differentially affect spontaneous and evoked neurotransmitter release in hippocampal neurons.

The paper investigates input sources to layer 1 of mouse somatosensory cortex using retrograde tracing and optogenetics, revealing local and long-range contributions and their interactions.

The paper develops postsynaptic-targeted glutamate sensors to improve specificity and reliability of synaptic transmission measurements.

The paper shows that Dynamin 1xA forms molecular condensates with Syndapin 1 at endocytic sites, enabling ultrafast endocytosis by bypassing the recruitment step.

The paper investigates how Syntaxin-1A's juxtamembrane and transmembrane domains modulate vesicle fusion in neurons through palmitoylation, identifying distinct mechanisms for spontaneous and Ca2+-evoked release.

This study reexamines the roles of Syntaxin-1's N-peptide and Habc-domain in synaptic vesicle fusion using a mouse model, showing the Habc-domain is essential while the N-peptide has regulatory functions.

This study investigates how mutations in the C1C2B region of Munc13-1 affect neurotransmitter release and presynaptic plasticity in murine hippocampal cultures.

The paper identifies bi-allelic variants in TSPOAP1 as a cause of autosomal recessive dystonia, showing different clinical presentations based on variant type.

The paper reveals a nanoscale tripartite complex at glutamatergic synapses formed by Ca2+-channels, vesicles, and AMPA receptors, showing their functional coordination in neurotransmission.

The paper introduces synaptoPAC, an optogenetic tool that induces presynaptic plasticity by increasing transmitter release at specific brain synapses.

This study investigates the role of Vglut2 in dopamine neuron plasticity and post-lesional striatal reinnervation, finding that Vglut2 expression can be reactivated in adult neurons to support axonal recovery.

This study identifies how complexin suppresses spontaneous exocytosis by binding the membrane-proximal regions of VAMP2 and SNAP25.

This study shows RIM-BP2 has different roles in neurotransmitter release at hippocampal mossy fiber and pyramidal CA3-CA1 synapses, with RIM-BP2 promoting vesicle docking/priming at mossy fibers by recruiting Munc13-1.

This study shows Piccolo is essential for synaptic vesicle recycling through Pra1 and Rab5, linking its dysfunction to neurological disorders.

This study uses light-induced ROS to control SV protein damage and shows that autophagy rapidly clears damaged proteins in mouse hippocampal neurons, maintaining synaptic function.