Thorsten Trimbuch

The paper shows that SNARE complex proteins inhibit NALCN channel activity and that reducing NALCN currents promotes cell survival in syntaxin-depleted cells.

This study identifies two distinct regions in the synaptotagmin-1/SNARE complex interface that mediate different functions in neurotransmitter release and shows that Ca2+ triggers a rearrangement of this interface.

The paper introduces ROInet-seq, a method to map brain-wide monosynaptic connectivity using barcoded rabies virus and RNA-sequencing, revealing preserved regional network motifs in cortical areas.

This study investigates the role of the C-terminal half of the SNARE domain of Syntaxin-1A in synaptic vesicle stability and neurotransmitter release regulation.

The paper identifies specific amino acid residues in the complexin N-terminus that differentially affect spontaneous and evoked neurotransmitter release in hippocampal neurons.

The paper investigates input sources to layer 1 of mouse somatosensory cortex using retrograde tracing and optogenetics, revealing local and long-range contributions and their interactions.

The paper shows that Dynamin 1xA forms molecular condensates with Syndapin 1 at endocytic sites, enabling ultrafast endocytosis by bypassing the recruitment step.

The paper investigates how Syntaxin-1A's juxtamembrane and transmembrane domains modulate vesicle fusion in neurons through palmitoylation, identifying distinct mechanisms for spontaneous and Ca2+-evoked release.

This study reexamines the roles of Syntaxin-1's N-peptide and Habc-domain in synaptic vesicle fusion using a mouse model, showing the Habc-domain is essential while the N-peptide has regulatory functions.

This study investigates how mutations in the C1C2B region of Munc13-1 affect neurotransmitter release and presynaptic plasticity in murine hippocampal cultures.

The paper reveals a nanoscale tripartite complex at glutamatergic synapses formed by Ca2+-channels, vesicles, and AMPA receptors, showing their functional coordination in neurotransmission.

This study investigates the role of Vglut2 in dopamine neuron plasticity and post-lesional striatal reinnervation, finding that Vglut2 expression can be reactivated in adult neurons to support axonal recovery.

This study identifies how complexin suppresses spontaneous exocytosis by binding the membrane-proximal regions of VAMP2 and SNAP25.

This study shows HERV-K(HML-2) RNA activates TLR8 and Tlr7, causing neurodegeneration in mice and correlating with AD in humans.

This study uses light-induced ROS to control SV protein damage and shows that autophagy rapidly clears damaged proteins in mouse hippocampal neurons, maintaining synaptic function.

The paper identifies a PRG1 mutation that modifies SCN1A-related epilepsy in humans by exacerbating seizure susceptibility in a mouse model.