The molecular mechanism of on-demand sterol biosynthesis at organelle contact sites
Naama Zung, Nitya Aravindan, Angela Boshnakovska, Rosario Valenti, Noga Preminger, Felix Jonas, Gilad Yaakov, Mathilda M. Willoughby, Bettina Homberg, Jenny Keller, Meital Kupervaser, Nili Dezorella, Tali Dadosh, Sharon G. Wolf, Maxim Itkin, , Maya Schuldiner
This study identifies Yet3 as a protein that recruits sterol biosynthesis enzymes to ER contact sites, enabling on-demand sterol production and influencing organellar structure and function.
bioRxiv · May 9, 2024 · PreprintCell Biology