Doron Rapaport

This study identifies Vlf1 as a vacuolar lipophagy regulator in S. cerevisiae, showing its localization to the vacuole and interaction with Atg15, with effects on autophagy levels.

The paper identifies a dynamic displacement mechanism in mitochondrial protein import, showing that a flexible segment of Tom22 facilitates precursor protein release.

The paper shows that Zuo1, a ribosome-associated complex chaperone, mitigates growth defects and translation reduction in yeast with mitochondrial import defects under heat stress.

The paper shows MTCH1 can function as an insertase in mitochondria, compensating for the loss of the yeast MIM complex and restoring mitochondrial biogenesis and morphology.

This study identifies Mpf1 as a novel factor influencing the dual targeting of tail-anchored proteins between mitochondria and peroxisomes in yeast.

This study characterizes Tgl2, a putative TAG lipase in yeast mitochondria, showing its dimerization, catalytic residues, and role in mitochondrial lipid homeostasis.

This study identifies Yet3 as a protein that recruits sterol biosynthesis enzymes to ER contact sites, enabling on-demand sterol production and influencing organellar structure and function.

This study identifies PINK1's role in regulating mitochondrial function, lipid metabolism, and dopamine homeostasis in dopaminergic neurons, showing that cholesterol depletion can reverse PINK1-related phenotypes.