Mapping Alzheimer Disease Molecular Pathologies in Large-Scale Connectomics Data: A Publicly Accessible Correlative Microscopy Resource
Xiaomeng Han, Peter H. Li, Shuohong Wang, Tim M. Blakely, Sneha Aggarwal, Bhavika Gopalani, Morgan Sanchez, Richard Lee Schalek, Yaron Meirovitch, Zudi Lin, Daniel Raimund Berger, Yuelong Wu, Fatima Aly, Sylvie Bay, Benoı̂t Delatour, , Jeff William Lichtman
The paper presents a vCLEM protocol to map Aβ and pTau in AD mouse hippocampus connectomics data, revealing new molecular and structural alterations.
bioRxiv · Oct 24, 2023 · PreprintNeuroscience