Sylvie Bay

An optonanobody for reversible photoactivation of recombinant and native alpha;7 nicotinic

The paper introduces an optonanobody that reversibly photoactivates native alpha7 nicotinic receptors without genetic modification, demonstrating its effectiveness in Xenopus oocytes and hippocampal slices.

Mapping Alzheimer Disease Molecular Pathologies in Large-Scale Connectomics Data: A Publicly Accessible Correlative Microscopy Resource

The paper presents a vCLEM protocol to map Aβ and pTau in AD mouse hippocampus connectomics data, revealing new molecular and structural alterations.

Endogenous pathology in tauopathy mice progresses via brain networks

The paper uses whole-brain imaging to show that tau pathology in mice propagates retrogradely through brain networks.