Yuelong Wu

Connectome analysis of a cerebellum-like circuit for sensory prediction

The paper uses connectomics to map a cerebellum-like circuit in weakly electric fish, revealing structured synaptic connectivity that supports predictive sensory processing and continual learning.

RAEM: random-access electron microscopy for revisitable 3D imaging

RAEM enables targeted, multi-resolution imaging of biological specimens by combining low-resolution 3D surveys with high-resolution imaging of specific regions.

FEABAS: A Stitching and Alignment Tool for Serial EM Data

FEABAS is a tool for efficiently aligning and stitching serial EM data, handling artifacts and enabling scalable vEM reconstruction.

Probing Molecular Diversity and Ultrastructure of Brain Cells with Fluorescent Aptamers

This paper introduces CAptVE, a method for fluorescent aptamer-based labeling that enables molecular analysis in ultrastructurally reconstructable electron micrographs.

SmartEM: machine-learning guided electron microscopy

SmartEM accelerates electron microscopy image acquisition by using machine learning to intelligently allocate imaging time, achieving up to 7-fold speedup in connectomic samples.

Developmental Connectomics of the Mouse Cerebellum

This study investigates synaptic connectivity development in the mouse cerebellum, revealing sequential input-dependent wiring and individualized parallel fiber inputs to Purkinje cells.

A connectomic resource for neural cataloguing and circuit dissection of the larval zebrafish brain

The paper presents a connectomic dataset of a larval zebrafish brain, enabling circuit analysis through synaptic and neuronal annotations.

Correlative light and electron microscopy identifies circuit motifs underlying processing of noisy visual motion in larval zebrafish

The paper uses correlative light and electron microscopy to identify synaptic motifs in larval zebrafish that support visual motion processing.

Paired and solitary ionocytes in the zebrafish olfactory epithelium

The paper characterizes ionocyte subtypes in zebrafish olfactory epithelium, identifying three types with distinct functions and distributions.

A connectomic study of a petascale fragment of human cerebral cortex

The paper presents a connectomic analysis of a human cerebral cortex fragment, revealing structural and connectivity features of neurons and synapses.

Mapping Alzheimer Disease Molecular Pathologies in Large-Scale Connectomics Data: A Publicly Accessible Correlative Microscopy Resource

The paper presents a vCLEM protocol to map Aβ and pTau in AD mouse hippocampus connectomics data, revealing new molecular and structural alterations.

A Scalable Staining Strategy for Whole-Brain Connectomics

The paper introduces a 12-step protocol called ODeCO to infiltrate osmium in whole mouse brains, preserving ultrastructure for connectome mapping.

Connectomics of the Octopus vulgaris vertical lobe provides insight into conserved and novel principles of a memory acquisition network

The paper analyzes the connectome of the Octopus vulgaris vertical lobe, identifying novel synaptic structures and functional roles in memory acquisition.

Multiplexed volumetric CLEM enabled by antibody derivatives provides new insights into the cytology of the mouse cerebellar cortex

The paper introduces a vCLEM method using fluorescent scFvs to combine molecular labeling with ssEM, revealing new cell types and subcellular features in mouse cerebellar cortex.

Post-embryonic maturation of the C. elegans motor circuit

The paper reconstructs the post-embryonic maturation of the C. elegans motor circuit using electron microscopy, showing how structural rewiring maintains functional output during development.

Connectomes across development reveal principles of brain maturation

This study uses connectomics to show how brain circuits change with age in C. elegans, revealing principles of brain maturation through structural and functional remodeling.