The protease inhibitor Nirmatrelvir synergizes with inhibitors of GRP78 to suppress SARS-CoV-2 replication
Doha Al Krad, Kim M. Stegmann, Antje Dickmanns, Priya Kumar, Claudia Blaurock, Björn-Patrick Mohl, Sina Jasmin Wille, Angele Breithaupt, Tobias Britzke, Anne Balkema‐Buschmann, Matthias Dobbelstein
This study shows that combining Nirmatrelvir with GRP78 inhibitors strongly reduces SARS-CoV-2 replication in vitro and in a hamster model.
Antiviral Research · Jul 29, 2025Peer-reviewedMicrobiology