Catalytic-independent functions of INTAC in conferring sensitivity to BET inhibition
Pengyu Fan, Xue-Ying Shang, Aixia Song, Shuo Chen, Run-Yuan Mao, Jiwei Chen, Zhenning Wang, Hai Zheng, Bolin Tao, Wei Xu, Wei Jiang, Huijuan Yang, Congling Xu, Peng Zhang, Hai Jiang, Fei Chen
The paper identifies that BET inhibitor efficacy depends on the INTAC complex's auxiliary module, which interacts with the RACK7/ZMYND8-KDM5C complex to remove H3K4 methylation, thereby restoring sensitivity to BET inhibitors through WDR5 degradation.
bioRxiv · Feb 7, 2024 · PreprintMolecular Biology