Author

Congling Xu

Tongji UniversityORCID 0000-0003-0476-975XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Aixia SongiD· 2 shared Fei CheniD· 2 shared Hai ZhengiD· 2 shared Bolin Tao· 1 shared Hai JiangiD· 1 shared Huijuan YangiD· 1 shared Jingdong ChengiD· 1 shared Jiwei CheniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Aixia SongORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintFeb 25, 2024

Stabilization of Integrator/INTAC by the small but versatile DSS1 protein

Congling Xu, Qian-Xing Zhou, Hai Zheng…·Fei Chen

This study identifies DSS1 as an essential subunit of the INTAC complex, showing its role in stabilizing INTAC and its impact on transcriptional regulation.

1 citation

humanexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintFeb 7, 2024

Catalytic-independent functions of INTAC in conferring sensitivity to BET inhibition

Pengyu Fan, Xue-Ying Shang, Aixia Song…·Fei Chen

The paper identifies that BET inhibitor efficacy depends on the INTAC complex's auxiliary module, which interacts with the RACK7/ZMYND8-KDM5C complex to remove H3K4 methylation, thereby restoring sensitivity to BET inhibitors through WDR5 degradation.

2 citations

𝕏 PostBluesky