Author

Bradley R. Smith

University of Rochester Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

Benjamin J. Rodems· 2 shared Cameron D. BakeriD· 2 shared Christina M. Kaszuba· 2 shared Edgardo I. Franco· 2 shared Francisco A. ChavesiD· 2 shared Jane L. LiesveldiD· 2 shared Jeevisha BajajiD· 2 shared Laura Maria CalviiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

Benjamin J. Rodems

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Inosine misincorporation into mRNA triggers the integrated stress response and activates an innate immune gene expression signature

Jacob H Schroader, Naa N. Adade, Emmanuel E. Adade, Mark A. Bratslavsky, Hannah K. Shorrock, Bradley R. Smith, Ting Zhou, Steven Lotz, Taylor B. Bertucci, Sally Temple, Alex M. Valm, Cara Theresia Pager, J. Andrew Berglund, Mark T. Handley, Gabriele Fuchs, Kaalak Reddy

This study shows that inosine misincorporation into mRNA activates the integrated stress response and an innate immune gene expression signature, linking ITPase deficiency to cellular stress.

bioRxiv · Jan 17, 2026 · PreprintMolecular Biology

Taurine Transporter SLC6A6 Expression Promotes Mesenchymal Stromal Cell Function

Christina M. Kaszuba, Benjamin J. Rodems, Sonali Sharma, Cameron D. Baker, Edgardo I. Franco, Takashi Ito, Palomi Schacht, Kyle Jerreld, Emily A. Johnson, Bradley R. Smith, Chen Yu, Emily R. Quarato, Francisco A. Chaves, Jane L. Liesveld, Laura Maria Calvi, , Jeevisha Bajaj

This study shows that taurine transporter SLC6A6 promotes mesenchymal stromal cell function by supporting osteogenic differentiation and hematopoietic stem cell maintenance.

Cell Death and Disease · Jan 8, 2026Peer-reviewedCell Biology

Temporal Single Cell Analysis of Leukemia Microenvironment Identifies Taurine-Taurine Transporter Axis as a Key Regulator of Myeloid Leukemia

Sonali Sharma, Benjamin J. Rodems, Cameron D. Baker, Christina M. Kaszuba, Edgardo I. Franco, Bradley R. Smith, Takashi Ito, Kyle Swovick, Kevin A. Welle, Yi Zhang, Philip J. Rock, Francisco A. Chaves, Sina Ghaemmaghami, Laura Maria Calvi, Archan Ganguly, , Jeevisha Bajaj

This study identifies the taurine-taurine transporter axis as a critical regulator of myeloid leukemia using temporal single-cell RNA-sequencing and functional experiments.

Nature · May 14, 2025Peer-reviewedCancer Biology