Gabriele Fuchs

This study shows that inosine misincorporation into mRNA activates the integrated stress response and an innate immune gene expression signature, linking ITPase deficiency to cellular stress.

This paper introduces a method to temporally control CRISPR-Cas9 activity using bio-orthogonal chemistry, demonstrating its effectiveness in live cells and therapeutic applications.

The paper identifies a translation control module involving RNA helicases that links ribosome biogenesis to germline stem cell differentiation in Drosophila.

This study shows that RACK1 enhances poliovirus translation and infection by facilitating viral IRES-mediated translation, with reduced RACK1 leading to smaller viral plaques and delayed host translational shut-off.

This study shows Gli3 is critical for olfactory ensheathing cell development and GnRH-1 neuronal migration, and identifies a GLI3 mutation in a Kallmann syndrome patient.

The paper identifies a conserved 10-nucleotide sequence in maternal mRNAs that is bound by different RNA-binding proteins at different stages of oogenesis to regulate translation.