Reversible Dissociation of Mitochondrial Complex V Balances Anabolic and Energy-Generating Needs in Cancer
Huabo Wang, Jie Lu, Colin Henchy, Steven J. Mullett, Adam C. Richert, Eric S. Goetzman, Ahmet Toksoz, Leonardo Hale, Brandon B. Wang, Nelli Mnatsakanyan, Edward V. Prochownik
The paper shows that dissociation of mitochondrial Complex V into Fo and F1 domains balances anabolic and energy needs in cancer cells by uncoupling ATP synthesis from TCA cycle activity.
iScience · Feb 3, 2026Peer-reviewedCancer Biology