Caesar Z. Li

Reversal of Biological Age in Multiple Rat Organs by Young Porcine Plasma Fraction

This study shows that young porcine plasma treatment reduces epigenetic age in multiple rat organs and improves physiological function.

Universal DNA methylation age across mammalian tissues

The paper develops universal epigenetic clocks that accurately estimate age across mammalian tissues using DNA methylation data from 185 species.

A mammalian methylation array for profiling methylation levels at conserved sequences

The paper develops a mammalian methylation array to profile methylation levels at conserved sequences across species, enabling cross-species comparisons and epigenetic biomarker development.

Epigenetic clock and methylation studies in vervet monkeys

The paper develops DNA methylation-based age estimators for vervet monkeys and shows evolutionary conservation of epigenetic aging in primates.

Epigenetic clock and DNA methylation analysis of porcine models of aging and obesity

The paper develops epigenetic clocks for pigs and identifies methylation differences between domestic and minipigs, linking them to obesity and aging-related genes.

Multi-tissue methylation clocks for age estimation in the common bottlenose dolphin

The paper develops methylation-based age estimation clocks for bottlenose dolphins using blood and skin samples, achieving high accuracy with median absolute errors under 3 years.

Epigenetic clock and methylation studies in cats

This paper develops epigenetic clocks for domestic cats using methylation profiles from a custom Infinium array, creating three clocks including dual-species human-cat clocks.

Epigenetic clock and methylation study of oocytes from a bovine model of reproductive aging

This paper develops epigenetic clocks for bovine oocytes and evaluates their ability to estimate chronological age and reveal differences in aging between oocytes and blood.

Epigenetic models predict age and aging in plains zebras and other equids

The paper develops epigenetic clocks and pacemaker models to predict age in plains zebras and other equids using DNA methylation data from blood samples.

DNA methylation clocks show slower progression of aging in naked mole-rat queens

This study develops DNA methylation clocks for naked mole-rats and finds that queens age more slowly than non-breeders, suggesting a link between reproductive status and epigenetic aging.

Genome Methylation Predicts Age and Longevity of Bats

This study uses DNA methylation profiles from bats to show that age and longevity are linked to specific methylation patterns, with longevity associated with immune and cancer-related genes.

Pair bonding slows epigenetic aging and alters methylation in brains of prairie voles

This study develops DNA methylation-based age estimators for prairie voles and finds that pair bonding slows epigenetic aging and alters methylation in brain tissue.

Reversing age: dual species measurement of epigenetic age with a single clock

This study develops epigenetic clocks for rat and human tissues and shows that young plasma treatment reduces epigenetic age in multiple tissues and improves organ function.