Author

Brian E. Hew

University of Hawaiʻi at Mānoa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

Jesse B. OwensiD· 3 shared Christopher T Tran· 2 shared David F. WalleriD· 2 shared Ilko Stoytchev· 2 shared James E Short· 2 shared Lisa Sharek· 2 shared Ahmed H. BadraniD· 1 shared Amanda J. Lee· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMolecular Biology

Jesse B. OwensORCID

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Author profile →

3 papers

Recent·Most cited

The exocyst is an insulin-sensitive regulator of amyloid precursor protein trafficking and amyloid-beta generation in neurons

Chantell Balaan, Geetika Y. Patwardhan, Rachel K Sachs, Hanna Kumasaka, Swasthita Sadagopan, Shion Aou, Amanda J. Lee, Luke T. Nelson, Brian E. Hew, Jesse B. Owens, Noémi Polgár, Michael A. Ortega, Robert A. Nichols, Ben Fogelgren

The paper shows the exocyst regulates APP trafficking and amyloid-beta generation in neurons, with insulin signaling shifting exocyst activity away from APP to GLUT4.

bioRxiv · Apr 17, 2026 · PreprintNeuroscience

Gene-sized DNA insertion at genomic safe harbors in human cells using a site-directed transposase

James E Short, Lisa Sharek, Joshua F. Meckler, Ilko Stoytchev, Christopher T Tran, Clara Errard, Brian E. Hew, Brandon E. Johnson, David F. Waller, Shanfu Xie, Joseph J Higgins, Raymond Tabibiazar, Jesse B. Owens

This paper develops a site-directed transposase system for precise genomic insertion of gene-sized DNA without double-strand breaks, achieving on-target insertion with minimal off-target effects.

Nucleic Acids Research · Nov 5, 2025Peer-reviewedMolecular Biology

Directed evolution of hyperactive integrases for site specific insertion of transgenes

Brian E. Hew, Sabranth Gupta, Ryuei Sato, David F. Waller, Ilko Stoytchev, James E Short, Lisa Sharek, Christopher T Tran, Ahmed H. Badran, Jesse B. Owens

The paper develops hyperactive integrases through directed evolution to efficiently insert large transgenes into specific genomic sites.

Nucleic Acids Research · Jun 11, 2024Peer-reviewedMolecular Biology