Author

Amanda J. Lee

Kapiolani Community College

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Ben FogelgreniD· 2 shared Geetika Y. PatwardhaniD· 2 shared Michael A. OrtegaiD· 2 shared Alexis BrakeiD· 1 shared B. FujimotoiD· 1 shared Brian E. Hew· 1 shared Chantell Balaan· 1 shared Daniel H. GeschwindiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Ben FogelgrenORCID

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Author profile →

3 papers

Recent·Most cited

The exocyst is an insulin-sensitive regulator of amyloid precursor protein trafficking and amyloid-beta generation in neurons

Chantell Balaan, Geetika Y. Patwardhan, Rachel K Sachs, Hanna Kumasaka, Swasthita Sadagopan, Shion Aou, Amanda J. Lee, Luke T. Nelson, Brian E. Hew, Jesse B. Owens, Noémi Polgár, Michael A. Ortega, Robert A. Nichols, Ben Fogelgren

The paper shows the exocyst regulates APP trafficking and amyloid-beta generation in neurons, with insulin signaling shifting exocyst activity away from APP to GLUT4.

bioRxiv · Apr 17, 2026 · PreprintNeuroscience

A 4D transcriptomic map for the evolution of multiple sclerosis-like lesions in the marmoset brain

Jing‐Ping Lin, Alexis Brake, Maxime Donadieu, Amanda J. Lee, Ginger Smith, Kevin Hu, Govind Nair, Riki Kawaguchi, Pascal Sati, Daniel H. Geschwind, Steven Jacobson, Dorothy P. Schafer, Daniel S. Reich

The paper identifies spatiotemporal diversity of primate brain cells during white matter inflammatory demyelination using a cross-modality approach to inform lesion detection and management in multiple sclerosis.

Science · Feb 27, 2025Peer-reviewedNeuroscience

Exocyst Inactivation in Urothelial Cells Disrupts Autophagy and Activates non-canonical NF-kB

Michael A. Ortega, Ross Villiger, Malia H. Harrison-Chau, Suzanna Lieu, Kadee‐Kalia Tamashiro, Amanda J. Lee, B. Fujimoto, Geetika Y. Patwardhan, Joshua K. Kepler, Ben Fogelgren

This study shows that Exoc5 ablation disrupts autophagy in urothelial cells, activates non-canonical NF-κB signaling, and leads to ureter obstruction.

Disease Models & Mechanisms · Aug 25, 2022Peer-reviewedDevelopmental Biology