Karthik Nagapudi

DSPE-PEG does not retain targeting antibodies on LNP surfaces in vivo; a higher molecular weight anchor is required

This study shows that DSPE-PEG fails to retain mAbs on LNPs in vivo, while a higher molecular weight PCL-b-PEG anchor maintains stability, highlighting the importance of anchoring strength for extrahepatic delivery.

Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

This study evaluates bifunctional ER degraders with different ubiquitin ligase ligands, finding that pan-IAP antagonists enhance ER degradation and induce TNF-dependent cell death more effectively than existing therapies.