Metabolite mimicry identifies butyrate analogs with select protective functions in the intestinal mucosa
Alfredo Ornelas, Jacob A. Countess, Ji Yeon Kim, Rachel H. Cohen, Brittany Gomez, Rebecca L. Roer, Faiz Minhajuddin, Kiranmayee Yenugudhati Vijaya Sai, Liheng Zhou, Julia L.M. Dunn, Caleb Chandler, Philip Reigan, Ian M. Cartwright, Caroline H. T. Hall, Geetha Bhagavatula, , Sean P. Colgan
This study identifies a butyrate analog, 3-chlorobutyrate, that enhances epithelial barrier formation and is protective in colitis without affecting intestinal stem cells.
Proceedings of the National Academy of Sciences · Apr 9, 2026Peer-reviewedMolecular Biology