This study identifies a butyrate analog, 3-chlorobutyrate, that enhances epithelial barrier formation and is protective in colitis without affecting intestinal stem cells.

Proceedings of the National Academy of Sciences · Apr 9, 2026Peer-reviewedMolecular Biology

Effects of C3aR activated mast cells in eosinophilic esophagitis

Simin Zhang, Dalila Cavallaro, Ming Xia, Netali Ben-Baruch Morgenstern, Tetsuo Shoda, Garrett A. Osswald, Scott M. Bolton, Vincent A. Mukkada, Tahereh Mina Derakhshan, Julia L.M. Dunn, Jennifer M. Felton, Mark Rochman, Julie M. Caldwell, Marc E. Rothenberg

This study investigates the role of C3aR-activated mast cells in eosinophilic esophagitis, showing increased degranulation and cytokine release in EoE patients.

bioRxiv · May 23, 2025 · PreprintImmunology

Three Distinct Transcriptional Profiles of Monocytes Correlate with Disease Activity in SSc Patients

Hadijat M. Makinde, Julia L.M. Dunn, Gaurav T. Gadhvi, Mary A. Carns, Kathleen Aren, Anh H Chung, Lutfiyya N. Muhammad, Jing Song, Carla Marie Cuda, Salina T. Dominguez, John Erik Pandolfino, Jane E. Dematte D’Amico, G. R. Scott Budinger, Shervin Assassi, Tracy Frech, , Deborah R. Winter

This study identifies three monocyte transcriptional subgroups in SSc patients that correlate with disease activity, particularly lung function.

bioRxiv · Jan 29, 2022 · PreprintGenomics