S. Carvalho

Stable long-term individual variation in chimpanzee technological efficiency

This study investigates long-term individual variation in chimpanzee nut-cracking efficiency over 25 years, finding stable differences that challenge previous sex-based conclusions.

A network-based analysis of signal use during approach interactions across sexes in chacma baboons (Papio ursinus griseipes)

The paper analyzes signal use in approach interactions across sexes in chacma baboons, identifying predictable signal combinations and their association with benign intent.

Chimpanzee play sequences are structured hierarchically as games

This study shows chimpanzee play sequences are hierarchically structured as games with predictable patterns and flexible action rules.

Rock inhibitors target SRSF2 leukemia by disrupting cell mitosis and nuclear morphology

This study identifies ROCK inhibitors as effective targeting agents for SRSF2 mutant leukemia by disrupting mitosis and nuclear morphology in vitro and in xenograft models.

YAP restricts renal inflammation and mitigates kidney damage in nephronothisis related kidney disease.

This study investigates the role of YAP in NPH-like kidney disease and finds that YAP inhibition is not therapeutic, suggesting LKB1 and YAP are parallel regulators of a harmful pathway.

The first Miocene fossils from coastal woodlands in the southern East African Rift

The paper reports the discovery of the first Miocene fossil sites in Gorongosa National Park, Mozambique, providing radiometric dates, vegetation reconstructions, and fossil tooth descriptions.

Landscaping the behavioural ecology of primate stone tool use

This study examines the ecological factors influencing nut-cracking behavior in wild chimpanzees, finding that food availability and nest proximity are key predictors of tool-use sites.

Adsorption of Lysozyme Into a Charged Confining Pore

This study examines how pH, salt concentration, and pore radius affect the orientation and residue distribution of lysozyme adsorbed into a charged silica pore using simulations.

RAMPs regulate signalling bias and internalisation of the GIPR

This study shows RAMPs modulate GIPR signaling and internalization, with RAMP3 reducing cAMP production and promoting surface retention, while RAMP1/2 decrease Gq/11/15 activation, and RAMP1 is essential for normal glucose regulation.

DNA damage independent inhibition of NF-κB transcription by anthracyclines

This study shows anthracyclines inhibit NF-κB transcription without DNA damage, affecting inflammation independently of their DNA-damaging effects.

Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression

The paper identifies BnOCPA as an A1R agonist that selectively activates Gαob, providing analgesia without cardiorespiratory depression.

Overcoming insecticide resistance through computational inhibitor design

The paper designs boronic acid inhibitors to overcome insecticide resistance by targeting carboxylesterases in pests, significantly enhancing insecticide efficacy and reducing usage.

Polygenicity And Epistasis Underlie Fitness-Proximal Traits In The Caenorhabditis elegans Multiparental Experimental Evolution (CeMEE) Panel

The paper uses the CeMEE panel to study the genetic basis of fertility and body size in C. elegans, finding that epistasis, not common additive alleles, explains significant trait variance.