Author

M. A. Siraj

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

R. Tseng· 2 shared A. Dey· 1 shared A. Driouchi· 1 shared A. O. Gramolini· 1 shared B. Chen· 1 shared C. A. Simmons· 1 shared C. M. Yip· 1 shared C. V. Leiton· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

R. Tseng

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Author profile →

3 papers

Recent·Most cited

Activation of ERK by altered RNA splicing in cancer

Y. Zhang, M. A. Siraj, P. Chakraborty, R. Tseng, L.-T. Ku, S. Das, A. Dey, S. K. D. Dwivedi, G. Rao, M. Zhang, D. Yang, M. N. Hossen, W.-Q. Ding, K.-M. Fung, R. Bhattacharya, , P. Mukherjee

The paper shows that SMNDC1, an upregulated splicing factor in cancer, promotes tumor growth by enhancing ERK1 kinase activity through altered RNA splicing of exon 4.

bioRxiv · Aug 31, 2022 · PreprintCancer Biology

Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer

C.-H. Pan, N. Chaika, R. Tseng, M. A. Siraj, B. Chen, K. L. Donnelly, M. Horowitz, C. V. Leiton, S. Chowdhury, L. Roa-Pena, L. Oblein, N. Marchenko, P. K. Singh, K. R. Shroyer, L. F. Escobar-Hoyos

This study identifies K17-mediated pyrimidine biosynthesis as a mechanism of chemoresistance in PDAC and shows that targeting DHODH with Brequinar enhances the efficacy of chemotherapy.

bioRxiv · Aug 24, 2022Cancer Biology

Long-term functional culture and in vitro manipulation of adult mouse cardiomyocytes

N. I. Callaghan, S.-H. Lee, S. Hadipour-Lakmehsari, X. A. Lee, M. A. Siraj, A. Driouchi, C. M. Yip, M. Husain, C. A. Simmons, A. O. Gramolini

This study develops methods to culture adult mouse cardiomyocytes long-term, maintaining their structure and function for in vitro experiments and genetic manipulations.

Communications Biology · May 11, 2020Peer-reviewedCell Biology