Small Molecule Modulation of the Archetypal UbiB protein COQ8
N. H. Murray, A. Lewis, C. R. M. Asquith, J. P. R. Pabon, Z. Fang, N. Ptak, R. W. Smith, J. D. Vasta, C. A. Zimprich, C. R. Corona, M. B. Robers, C. A. Bingman, M. L. Gross, K. Henzler-Wildman, D. J. Pagliarini
The paper develops small molecule inhibitors and activators for COQ8A, a UbiB family protein, using crystallography, NMR, and mass spectrometry to modulate its function in CoQ biosynthesis.
bioRxiv · Mar 22, 2022 · PreprintBiochemistry