Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors
M. Saldivia, S. P. S. Rao, E. Fang, E. Myburgh, E. Brown, A. J. M. Wollman, R. Ritchie, S. B. Lakhsminarayana, Y. L. Chen, D. Patra, H. X. Koh, S. Williams, F. Supek, D. Paape, C. Bower-Lepts, , J. C. Mottram
This study identifies CLK1 as a novel drug target in Trypanosoma brucei by showing its essential role in kinetochore function and cell survival through kinase inhibition.
bioRxiv · Apr 24, 2019Microbiology