Author

E. Myburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

E. Brown· 2 shared J. C. Mottram· 2 shared N. Brown· 2 shared A. J. M. Wollman· 1 shared C. Bower-Lepts· 1 shared D. Paape· 1 shared D. Patra· 1 shared D. Perez-Mazliah· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

E. Brown

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Macrophage-derived developmental endothelial locus 1 (DEL-1) expression promotes an immunoprotective phenotype in experimental visceral leishmaniasis.

J. Lukaszonek, N. Brown, J. Zenga, E. Myburgh, J. P. Hewitson, G. Hajishengalis, T. Chavakis, P. M. Kaye, I. Kourtzelis

This study shows that DEL-1 expression in macrophages reduces parasite burden and granuloma formation in visceral leishmaniasis, promoting an immunoprotective response.

bioRxiv · Apr 24, 2024 · PreprintImmunology

UVB modifies skin immune-stroma cross-talk and promotes effector T cell recruitment during cryptic Leishmania donovani infection

M. Montes de Oca, S. Dey, K. Van Bocxlaer, H. Ashwin, N. Brown, E. Myburgh, N. S. Dey, G. F. Rani, E. Muscutt, M. Osman, D. Perez-Mazliah, S. James, L. Gilbert, M. Chatterjee, P. Kaye

This study uses scRNA-seq and spatial transcriptomics to show UVB exposure alters immune-stromal interactions and T cell recruitment during cryptic Leishmania donovani infection.

bioRxiv · Feb 3, 2023 · PreprintImmunology

TORC1 is an essential regulator of nutrient-dependent differentiation in Leishmania

E. Myburgh, V. Geoghegan, E. V. C. Alves-Ferreira, Y. R. Nievas, J. S. Grewal, E. Brown, K. McLuskey, J. C. Mottram

This study identifies TORC1 as essential for nutrient-dependent differentiation in Leishmania, showing its role in both promastigote and amastigote stages.

bioRxiv · Oct 20, 2022 · PreprintCell Biology

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

M. Saldivia, S. P. S. Rao, E. Fang, E. Myburgh, E. Brown, A. J. M. Wollman, R. Ritchie, S. B. Lakhsminarayana, Y. L. Chen, D. Patra, H. X. Koh, S. Williams, F. Supek, D. Paape, C. Bower-Lepts, , J. C. Mottram

This study identifies CLK1 as a novel drug target in Trypanosoma brucei by showing its essential role in kinetochore function and cell survival through kinase inhibition.

bioRxiv · Apr 24, 2019Microbiology