Author

F. Supek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. J. M. Wollman· 1 shared C. Bower-Lepts· 1 shared D. Paape· 1 shared D. Patra· 1 shared E. Brown· 1 shared E. Fang· 1 shared E. Myburgh· 1 shared H. X. Koh· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMicrobiology

A. J. M. Wollman

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2 papers

Recent·Most cited

Loss of HMCES is synthetic lethal with APOBEC activity in cancer cells

J. Biayna, I. Garcia-Cao, M. M. Alvarez, M. Salvadores, J. Espinosa-Carrasco, M. McCullough, F. Supek, T. H. Stracker

The paper identifies HMCES as a synthetic lethal partner of APOBEC3A in cancer cells, showing its role in protecting against DNA damage and its potential as a therapeutic target.

bioRxiv · Feb 5, 2021 · PreprintCancer Biology

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

M. Saldivia, S. P. S. Rao, E. Fang, E. Myburgh, E. Brown, A. J. M. Wollman, R. Ritchie, S. B. Lakhsminarayana, Y. L. Chen, D. Patra, H. X. Koh, S. Williams, F. Supek, D. Paape, C. Bower-Lepts, , J. C. Mottram

This study identifies CLK1 as a novel drug target in Trypanosoma brucei by showing its essential role in kinetochore function and cell survival through kinase inhibition.

bioRxiv · Apr 24, 2019Microbiology