S. Brun

Courtship ritual of male and female nuclei during fertilisation in Neurospora crassa

This study tracks male and female nuclei during fertilization in Neurospora crassa using live-cell imaging, revealing novel dynamics of nuclear movement and polyspermy avoidance.

GNS561, a new autophagy inhibitor active against cancer stem cells in hepatocellular carcinoma and hepatic metastasis from colorectal cancer

This study shows that GNS561, an autophagy inhibitor, effectively targets both cancer stem cells and bulk tumor cells in hepatocellular carcinoma and colorectal cancer metastasis.

GNS561, a clinical-stage PPT1 inhibitor, is efficient against hepatocellular carcinoma via modulation of lysosomal functions

This paper evaluates GNS561, a PPT1 inhibitor, showing its efficacy against HCC by modulating lysosomal functions and inducing cell death in vitro and in vivo.

Characterization of SARS-CoV-2 ORF6 deletion variants detected in a nosocomial cluster during routine genomic surveillance, Lyon, France

This study identifies two SARS-CoV-2 ORF6 deletion variants from genomic surveillance, showing nosocomial transmission and comparable replication kinetics but no significant clinical impact.