Long-term in vitro exposure of Treponema pallidum to sub-bactericidal doxycycline did not induce resistance: Implications for doxy-PEP and syphilis
L. C. Tantalo, A. Luetkemeyer, N. A. P. Lieberman, E. Nunley, C. Avendano, A. L. Greninger, C. Celum, L. Giacani
This study shows that long-term in vitro exposure of Treponema pallidum to sub-bactericidal doxycycline does not induce resistance, supporting the use of doxy-PEP for syphilis prevention.
bioRxiv · Jun 27, 2024 · PreprintMicrobiology