Author

J. R. Lingappa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 7 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2

Frequent Co-Authors

J. C. Reed· 5 shared D. J. Phuong· 3 shared V. R. Lingappa· 3 shared A. F. Lingappa· 2 shared A. Kitaygorodskyy· 2 shared A. Mueller-Schiffmann· 2 shared B. C. Barajas· 2 shared D. Dey· 2 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersMicrobiology

J. C. Reed

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy

A. F. Lingappa, O. Akintunde, C. Ewald, M. Froehlich, N. Ziari, M. Michon, S. F. Yu, S. Mallesh, J. Lin, A. Kitaygorodskyy, D. Solas, J. C. Reed, J. R. Lingappa, A. Mueller-Schiffmann, C. Korth, , V. R. Lingappa

The paper identifies two small molecules with pan-cancer cytotoxicity and validates their anti-tumor effects in xenograft models, showing they target TRIM28/KAP1-containing complexes involved in cancer survival.

bioRxiv · Sep 28, 2022Cancer Biology

A Pan-respiratory Antiviral Chemotype Targeting a Host Multiprotein Complex

M. Michon, A. Mueller-Schiffmann, A. F. Lingappa, S. F. Yu, L. Du, F. Deiter, S. Mallesh, J. Crabtree, U. F. Lingappa, A. Macieik, L. Mueller, P. N. Ostermann, M. Andree, O. Adams, H. Schaal, , K

The paper identifies a novel antiviral chemotype effective against multiple respiratory viruses by targeting a host multi-protein complex involved in viral lifecycle and innate immunity.

bioRxiv · Jan 17, 2021Biochemistry

Identification of an antiretroviral small molecule that appears to be a host-targeting inhibitor of HIV-1 assembly

J. C. Reed, D. Solas, A. Kitaygorodskyy, B. Freeman, D. T. B. Ressler, D. J. Phuong, J. V. Swain, K. Matlack, C. R. Hurt, V. R. Lingappa, J. R. Lingappa

This paper identifies two small molecules that inhibit HIV-1 assembly by targeting host factors involved in Gag assembly, showing efficacy against drug-resistant strains and lacking resistance mutations in Gag.

Journal of Virology · Jan 13, 2021Peer-reviewedMicrobiology

Neutralizing activity of broadly neutralizing anti-HIV-1 antibodies against primary African isolates

J. C. C. Lorenzi, P. Mendoza, Y. Z. Cohen, L. Nogueira, C. Lavine, J. Sapiente, M. Seaman, M. Wiatr, N. R. Mugo, A. Mujugira, S. Delany, J. R. Lingappa, C. Celum, M. Caskey, M. C. Nussenzweig

This study evaluates the neutralizing activity of 9 anti-HIV-1 bNAbs against primary African isolates, finding reduced potency and breadth compared to pseudotyped viruses.

bioRxiv · Sep 24, 2020Immunology

Treatment with commonly used antiretroviral drugs induces a type I/III interferon signature in the gut in the absence of HIV infection

S. M. Hughes, C. N. Levy, F. Calienes, J. D. Stekler, U. Pandey, L. Vojtech, A. R. Berard, K. Birse, L. Noel-Romas, B. Richardson, J. B. Golden, M. Cartwright, A. C. Collier, C. E. Stevens, M. E. Curlin, , F. Hladik

This study shows that oral TDF/FTC antiretroviral drugs induce a type I/III interferon signature in the gut without HIV infection, potentially affecting immune responses.

bioRxiv · Aug 3, 2020Immunology

Metagenomics for chronic meningitis: clarifying interpretation and diagnosis

M. R. Wilson, B. D. O'Donovan, J. M. Gelfand, H. A. Sample, F. C. Chow, J. P. Betjemann, M. P. Shah, M. B. Richie, M. P. Gorman, R. A. Hajj-Ali, L. H. Calabrese, K. C. Zorn, J. E. Greenlee, J. H. Blum, G. Green, , J. L. DeRisi

This study uses metagenomic next-generation sequencing of cerebrospinal fluid to identify pathogens in patients with subacute or chronic meningitis, using a z-score based scoring algorithm to distinguish true pathogens from environmental contaminants.

bioRxiv · Nov 7, 2017Microbiology

The ABCE1 capsid assembly pathway is conserved between primate lentiviruses and the non-primate lentivirus feline immunodeficiency virus

J. C. Reed, N. Westergreen, B. C. Barajas, D. Ressler, D. J. Phuong, J. V. Swain, V. R. Lingappa, J. R. Lingappa

This study shows that feline immunodeficiency virus (FIV) Gag forms assembly intermediates similar to HIV-1, involving ABCE1 and DDX6, indicating conserved viral-host interactions in lentivirus capsid assembly.

bioRxiv · Oct 22, 2017Microbiology

HIV-1 initiates genomic RNA packaging in a unique subset of host RNA granules

M. Tanaka, B. C. Barajas, B. A. Robinson, D. J. Phuong, K. Chutiraka, J. C. Reed, J. R. Lingappa

This paper identifies the packaging initiation complex of HIV-1 genomic RNA as a co-opted host RNA granule and defines the two-step mechanism by which Gag enters this granule to initiate RNA packaging.

bioRxiv · Sep 6, 2017Microbiology