J. M. Carreno

Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination

This study identifies non-neutralizing antibodies from vaccinated individuals that protect against SARS-CoV-2 in animal models, highlighting their role through Fc-mediated effector functions and conserved epitope binding.

Mucosal antibody responses to SARS-CoV-2 booster vaccination and breakthrough infection

This study compares mucosal antibody responses in individuals who received mRNA booster vaccinations or experienced breakthrough infections, finding that breakthrough infections induce stronger saliva sIgA responses than boosters.

Immunity to seasonal coronavirus spike proteins does not protect from SARS-CoV-2 challenge in a mouse model but has no detrimental effect on protection mediated by COVID-19 mRNA vaccination

This study investigates whether immunity to seasonal coronavirus spike proteins protects against SARS-CoV-2 in mice and affects mRNA vaccine efficacy, finding no increased protection but no detrimental effect on vaccination.

Receptor binding domain (RBD) antibodies contribute more to SARS-CoV-2 neutralization when target cells express high levels of ACE2

This study shows that RBD antibodies contribute more to SARS-CoV-2 neutralization when target cells have high ACE2 expression, highlighting ACE2 levels as a critical experimental factor.

Trivalent NDV-HXP-S vaccine protects against phylogenetically distant SARS-CoV-2 variants of concern in mice

The paper tests a trivalent NDV-HXP-S vaccine against SARS-CoV-2 variants in mice, showing increased protection and cross-neutralizing antibodies against Omicron.

Discovery of a SARS-CoV-2 Broadly-Acting Neutralizing Antibody with Activity against Omicron and Omicron + R346K Variants

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains

This study evaluates the protective efficacy of mRNA vaccines against SARS-CoV-2 variants in mice, showing that low-dose vaccines lead to breakthrough infections with Delta variant.

Structure of a germline-like human antibody defines a neutralizing epitope on the SARS-CoV-2 spike NTD

The paper structures a germline-like antibody in complex with SARS-CoV-2 spike NTD, revealing a neutralizing epitope and its conservation across variants.

Novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidase

This study identifies novel epitopes of human monoclonal antibodies targeting the influenza virus N1 neuraminidase and characterizes escape mutations and their impact on viral fitness.

Monoclonal antibodies targeting the influenza virus N6 neuraminidase

This study generates and characterizes monoclonal antibodies against the N6 neuraminidase subtype of influenza viruses, showing broad reactivity and antiviral activity, but limited inhibition of H5N6 NA.