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10 papers
Recent·Most cited
B. Ying, C.-Y. Liang, P. Desai, S. Scheaffer, S. Elbashir, D. K. Edwards, L. B. Thackray, M. S. Diamond
This study shows that boosting mice with mRNA vaccines in the ipsilateral or contralateral arm leads to equivalent immune responses and protection against SARS-CoV-2 Omicron.
Journal of Virology · Sep 17, 2024Peer-reviewedMicrobiology
P. Desai, C. E. Karl, B. Ying, C.-Y. Liang, T. Garcia-Salum, A. C. Santana, F. T. Caten, J. F. Urban, S. M. Elbashir, D. K. Edwards, S. P. Ribeiro, L. B. Thackray, R.-P. K. Sekaly, M. S. Diamond
This study shows that intestinal helminth infection reduces T cell responses to an mRNA SARS-CoV-2 vaccine and weakens protection against Omicron but not the ancestral strain.
bioRxiv · Jan 14, 2024 · PreprintImmunology
C.-Y. Liang, S. Raju, Z. Liu, Y. Li, G. A. Arunkumar, J. B. Case, S. J. Zost, C. M. Acreman, D. C. Carvalho dos Anjos, J. S. McLellan, J. E. Crowe, S. P. J. Whelan, S. M. Elbashir, D. K. Edwards, M. S. Diamond
This study shows that Omicron variant-matched boosters after prototype mRNA vaccines induce cross-neutralizing antibodies against SARS-CoV-2 and sarbecoviruses by imprinting prior immune responses.
bioRxiv · Jan 3, 2024 · PreprintImmunology
B. Ying, T. L. Darling, P. Desai, C.-Y. Liang, I. P. Dmitriev, N. Soudani, T. L. Bricker, E. A. Kashentseva, H. H. Harastani, A. G. Schmidt, D. T. Curiel, A. C. M. Boon, M. S. Diamond
This paper shows a bivalent ChAd nasal vaccine protects against SARS-CoV-2 BQ.1.1 and XBB.1.5 in mice and hamsters through mucosal immunity, despite poor serum neutralizing antibody responses.
bioRxiv · May 4, 2023 · PreprintMicrobiology
C.-Y. Liang, I. Huang, J. Han, S. Manivasagam, J. Plung, M. Sturtz, Y. Yu, M. Kandasamy, F. A. Gourronc, A. J. Klingelhutz, B. Choudhury, L. Rong, J. T. Perez, S. Neelamegham, B. Manicassamy
The paper shows human and avian influenza viruses use different glycoconjugate types for infection, with avian strains using a broader range.
bioRxiv · Jun 29, 2022Microbiology
B. Ying, S. M. Scheaffer, B. Whitener, C.-Y. Liang, O. Dmytrenko, S. Mackin, K. Wu, D. Lee, L. E. Avena, Z. Chong, J. B. Case, L. Ma, T. Kim, C. Sein, A. Woods, , M. S. Diamond
This study shows that boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibodies and protection against B.1.1.529 in mice, with the Omicron-matched booster showing slightly better outcomes.
bioRxiv · Feb 7, 2022 · PreprintMicrobiology
T. L. Darling, B. Ying, B. Whitener, L. VanBlargan, T. L. Bricker, C.-Y. Liang, A. Joshi, G. Bamunuarachchi, K. Seehra, A. Schmitz, P. Halfmann, Y. Kawaoka, S. Elbashir, D. K. Edwards, L. Thackray, , A. Boon
This study evaluates the efficacy of mRNA-1273 and Ad26.COV2.S vaccines against the B.1.621 variant in mice and hamsters, showing protection against infection and pathology.
bioRxiv · Dec 29, 2021Microbiology
B. Ying, B. Whitener, L. A. VanBlargan, A. O. Hassan, S. Shrihari, C.-Y. Liang, C. E. Karl, S. Mackin, R. E. Chen, N. M. Kafai, S. H. Wilks, D. J. Smith, J. M. Carreno, G. Singh, F. Krammer, , M. S. Diamond
This study evaluates the protective efficacy of mRNA vaccines against SARS-CoV-2 variants in mice, showing that low-dose vaccines lead to breakthrough infections with Delta variant.
bioRxiv · Aug 25, 2021Microbiology
J. Han, K. Ganti, V. K. Sali, C. Twigg, Y. Zhang, S. Manivasagam, C.-Y. Liang, O. A. Vogel, I. Huang, S. N. Emmanuel, J. Plung, L. Radoshevich, J. T. Perez, A. C. Lowen, B. Manicassamy
This study identifies Rab11a as a critical host factor for influenza A virus genome assembly by facilitating vRNP congregation and specific interactions.
bioRxiv · Apr 6, 2021Microbiology
O. A. Vogel, J. Han, C.-y. Liang, S. Manicassamy, J. T. Perez, B. Manicassamy
The paper shows that the p150 isoform of ADAR1 prevents sustained RIG-I signaling and apoptosis during influenza virus infection, independent of RNA editing.
bioRxiv · May 23, 2020Microbiology