Author

N. M. Kafai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Organism:human· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. S. Diamond· 4 shared R. E. Chen· 4 shared A. O. Hassan· 3 shared E. S. Winkler· 3 shared J. B. Case· 3 shared S. Shrihari· 3 shared A. L. Bailey· 2 shared B. Ying· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersMicrobiology

M. S. Diamond

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains

B. Ying, B. Whitener, L. A. VanBlargan, A. O. Hassan, S. Shrihari, C.-Y. Liang, C. E. Karl, S. Mackin, R. E. Chen, N. M. Kafai, S. H. Wilks, D. J. Smith, J. M. Carreno, G. Singh, F. Krammer, , M. S. Diamond

This study evaluates the protective efficacy of mRNA vaccines against SARS-CoV-2 variants in mice, showing that low-dose vaccines lead to breakthrough infections with Delta variant.

bioRxiv · Aug 25, 2021Microbiology

Ultrapotent miniproteins targeting the receptor-binding domain protect against SARS-CoV-2 infection and disease in mice

J. B. Case, R. E. Chen, L. Cao, B. Ying, E. S. Winkler, I. Goreshnik, S. Shrihari, N. M. Kafai, A. L. Bailey, X. Xie, P.-Y. Shi, R. Ravichandran, L. Carter, L. Stewart, D. Baker, M. S. Diamond

This study evaluates the protective efficacy of modified miniproteins against SARS-CoV-2 in mice, showing reduced viral burden and prevention of lung disease.

bioRxiv · Mar 1, 2021Microbiology

A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection

A. O. Hassan, N. M. Kafai, I. P. Dmitriev, J. M. Fox, B. Smith, I. B. Harvey, R. E. Chen, E. S. Winkler, A. W. Wessel, J. B. Case, E. Kashentseva, B. T. McCune, A. L. Bailey, H. Zhao, L. A. VanBlargan, , M. S. Diamond

A single intranasal dose of ChAd-SARS-CoV-2-S vaccine prevents SARS-CoV-2 infection and likely confers sterilizing immunity in mice.

bioRxiv · Jul 16, 2020 · PreprintMicrobiology

Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals

S. J. Zost, P. Gilchuk, J. B. Case, E. Binshtein, R. E. Chen, J. X. Reidy, A. Trivette, R. S. Nargi, R. E. Sutton, N. Suryadevara, L. E. Williamson, E. C. Chen, T. Jones, S. Day, L. Myers, , J. E. Crowe

The paper identifies potent neutralizing antibodies against SARS-CoV-2 that block receptor binding and protect animals, providing insights for vaccine and therapy development.

bioRxiv · May 22, 2020Immunology

Suppression of drug resistance reveals a genetic mechanism of metabolic plasticity in malaria parasites

A. M. Guggisberg, P. M. Frasse, A. J. Jezewski, N. M. Kafai, A. Y. Gandhi, S. J. Erlinger, A. R. Odom John

The paper identifies a genetic mechanism of metabolic plasticity in malaria parasites by uncovering HAD2 as a phosphatase regulating drug resistance and PFK9 as a suppressor of resistance.

bioRxiv · Jun 18, 2018Microbiology

A streamlined method for transposon mutagenesis of Rickettsia parkeri yields numerous mutations that impact infection

R. L. Lamason, N. M. Kafai, M. D. Welch

This study uses a transposon mutagenesis method to generate Rickettsia parkeri mutants, identifying genes involved in infection and host interactions.

bioRxiv · Mar 8, 2018Microbiology