Author

M. A. Quinn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:metabolism & bioenergetics· 5 Organism:mouse· 5 Approach:experimental assay· 4 Assay:metabolomics· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2

Frequent Co-Authors

R. Mainali· 3 shared C. Furdui· 2 shared C.-C. Key· 2 shared D. Long· 2 shared M. Zabalawi· 2 shared N. Buechler· 2 shared P. Stacpoole· 2 shared T. Oh· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersPhysiology

R. Mainali

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation

R. Mainali, N. Buechler, C. Ortero, L. Edwards, C.-C. Key, C. Furdui, M. A. Quinn

This study shows itaconate stabilizes CPT1a to enhance lipid utilization during inflammation, revealing a novel metabolic role in modulating fatty acid oxidation during sepsis.

bioRxiv · Aug 14, 2023Physiology

Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation

A. K. Meyers, Z. Wang, W. Han, Q. Zhao, M. Zabalawi, L. Duan, J. Liu, Q. Zhang, R. K. Manne, F. Lorenzo, M. A. Quinn, Q. Song, D. Fan, H.-K. Lin, C. M. Furdui, , X. Zhu

This study shows that inhibiting PDHK reduces NLRP3 inflammasome activation in macrophages, decreasing inflammation and tissue damage.

Cell Reports · Jan 1, 2023Peer-reviewedImmunology

Dichloroacetate improves systemic energy balance and feeding behavior during sepsis

T. Oh, M. Zabalawi, S. Jain, D. Long, P. Stacpoole, C. McCall, M. A. Quinn

This study shows that dichloroacetate improves energy balance and feeding behavior in sepsis by reversing metabolic dysfunctions and glycine deficiency.

bioRxiv · Jul 21, 2021Immunology

Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

R. Mainali, M. Zabalwi, D. Long, N. Buechler, E. Quillen, C.-C. Key, X. Zhu, J. Parks, C. Furdui, P. Stacpoole, J. Martinez, C. E. McCall, M. A. Quinn

This study shows dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction by targeting mitochondrial PDC/PDK energy homeostasis in a mouse model.

eLife · Feb 22, 2021Peer-reviewedImmunology

Itaconate and its derivatives repress C2C12 myogenesis

T. Oh, D. Hutchins, R. Mainali, K. Goslen, M. A. Quinn

This study shows itaconate and its derivatives inhibit C2C12 myogenesis by blocking succinate dehydrogenase, suggesting potential limitations in their therapeutic use for inflammatory diseases.

bioRxiv · Feb 1, 2021 · PreprintCell Biology

Impact of Advanced Maternal Age on Physiologic Adaptations to Pregnancy in Vervet Monkeys

M. Plant, C. Armstrong, A. Ruggiero, C. Sherrill, B. Uberseder, R. Jeffries, J. Nevarez, M. J. Jorgensen, K. Kavanagh, M. A. Quinn

This study examines the effects of advanced maternal age on pregnancy adaptations in vervet monkeys, finding physiological changes similar to human AMA pregnancies.

bioRxiv · Apr 6, 2020Physiology