G. Wong

Comparing multifunctional viral and eukaryotic proteins for generating scission necks in membranes

This study compares the membrane scission capabilities of viral and eukaryotic proteins using mechanical models and SAXS data to analyze how lipid composition and interfacial tension affect neck size.

Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML

The paper constructs a reference atlas of human hematopoiesis and maps AML differentiation patterns, revealing genetic and non-genetic factors driving aberrant differentiation in leukemia.

Extracellular disintegration of viral proteins as an innovative strategy for developing broad-spectrum antivirals against coronavirus

This paper introduces a new antiviral strategy using hyperanion-grafted enediyne molecules to disintegrate viral proteins, showing effectiveness against SARS-CoV-2 and other coronaviruses.

Non-motile subpopulations of Pseudomonas aeruginosa repress flagellar motility in motile cells through a type IV pili- and Pel-dependent mechanism

The paper shows non-motile Pseudomonas aeruginosa cells repress swarming motility in motile cells via type IV pili and Pel exopolysaccharide.

Force-induced changes of PilY1 drive surface sensing by Pseudomonas aeruginosa

This study shows that force-induced conformational changes in PilY1, a TFP tip protein, are required for surface sensing in Pseudomonas aeruginosa, affecting c-di-GMP signaling and biofilm formation.

Deep learning identifies pathological abnormalities predictive of graft loss in kidney transplant biopsies

This paper develops a deep learning model to quantify pathological features in kidney transplant biopsies, showing improved prediction of graft loss compared to clinical and Banff scores.

A potent synthetic nanobody targets RBD and protects mice from SARS-CoV-2 infection

Extended hopanoid loss reduces bacterial motility and surface attachment and leads to heterogeneity in root nodule kinetics in a Bradyrhizobium-Aeschynomene symbiosis

This study shows that loss of extended hopanoids in Bradyrhizobium reduces bacterial motility and surface attachment, leading to heterogeneous root nodule development in Aeschynomene afraspera.

Quality circles for quality improvement in primary health care: their effectiveness, gaps of knowledge, origins and significance - a scoping review

This scoping review evaluates quality circles in primary health care, finding they can effectively change behavior but require further research to understand their mechanisms and improve their use.