M. Duran

Named Entity Recognition of Pharmacokinetic parameters in the scientific literature

This paper introduces a novel corpus and language models for Named Entity Recognition of pharmacokinetic parameters in scientific literature, achieving high accuracy with BioBERT.

Phenotype-specific melanoma uptake of fatty acid from human adipocytes activates AXL and CAV1-dependent beta-catenin nuclear accumulation

The paper shows that MITFLow melanoma cells uptake fatty acids from adipocytes, activating AXL and CAV1 to drive beta-catenin nuclear accumulation, promoting invasion.

KMT2A oncoproteins induce epigenetic resistance to targeted therapies

This study shows KMT2A oncoproteins drive lineage-switching and epigenetic resistance in leukemia by dynamically binding chromatin and persisting as ENL-marked lesions despite therapy.

Renal Cl-/H+ antiporter ClC-5 regulates collagen production and release in Dent Disease models

This study shows that ClC-5 loss-of-function in Dent Disease models increases collagen production and release, contributing to renal fibrosis.

Epigenetic dysregulation from chromosomal transit in micronuclei

This study shows that chromosomal transit through micronuclei causes epigenetic dysregulation in cancer cells, leading to long-term chromatin accessibility abnormalities.

Global gene-expression analysis reveals the molecular processes underlying ClC-5 loss-of-function in novel Dent Disease 1 cellular models

The paper uses human proximal tubule cell models to study gene expression changes caused by ClC-5 loss-of-function mutations, revealing distinct molecular pathways affected by different mutations.

Palmitoylation of KChIP3 controls baseline mucin secretion

This study shows that palmitoylation of KChIP3 by zDHHC3 or zDHHC4 is required for its recruitment to mucin granules, thereby regulating baseline mucin secretion.