Author

D. H. Janssens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

S. Henikoff· 5 shared K. Ahmad· 3 shared J. F. Sarthy· 2 shared P. J. Paddison· 2 shared A. Bose· 1 shared A. D. Choudhury· 1 shared A. J. Kreitzman· 1 shared A.-L. Doebley· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersCancer Biology

S. Henikoff

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5 papers

Recent·Most cited

KMT2A oncoproteins induce epigenetic resistance to targeted therapies

D. H. Janssens, M. Duran, D. J. Otto, W. Wu, Y. Xu, D. Kirkey, C. G. Mullighan, J. S. Yi, S. Meshinchi, J. F. Sarthy, K. Ahmad, S. Henikoff

This study shows KMT2A oncoproteins drive lineage-switching and epigenetic resistance in leukemia by dynamically binding chromatin and persisting as ENL-marked lesions despite therapy.

bioRxiv · Dec 29, 2023 · PreprintCancer Biology

Epigenomic analysis of Formalin-Fixed Paraffin-Embedded samples by CUT&Tag

S. Henikoff, J. G. Henikoff, K. Ahmad, R. M. Paranal, D. H. Janssens, Z. R. Russell, F. Szulzewsky, S. Kugel, E. C. Holland

This study modifies the CUTAC protocol to enable high-resolution epigenomic analysis of FFPE samples, identifying regulatory element differences in mouse brain tumors.

bioRxiv · Jun 20, 2023Cancer Biology

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency

E. Hsieh, D. H. Janssens, P. J. Paddison, E. P. Browne, S. Henikoff, M. Ohainle, M. Emerman

This study uses a CRISPR screen to identify pathways involved in HIV-1 latency, finding that ING3 and AZD5582 combination activates proviruses.

bioRxiv · Aug 23, 2022Microbiology

Nucleosome patterns in circulating tumor DNA reveal transcriptional regulation of advanced prostate cancer phenotypes

N. De Sarkar, R. D. Patton, A.-L. Doebley, B. Hanratty, A. J. Kreitzman, J. F. Sarthy, M. Ko, M. Adil, S. Brahma, M. P. Meers, D. H. Janssens, L. S. Ang, I. Coleman, A. Bose, R. F. Dumpit, , G. Ha

This paper identifies nucleosome patterns in ctDNA that distinguish advanced prostate cancer phenotypes, achieving high accuracy in classification using a prediction model.

bioRxiv · Jun 21, 2022Cancer Biology

Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations

H. N. Thirmanne, F. Wu, D. H. Janssens, J. Swanger, H. Feldman, R. Amezquita, R. Gottardo, P. J. Paddison, S. Henikoff, B. E. Clurman

This study examines the transcriptional effects of Fbw7 mutations in colorectal cancer cells and identifies context-specific regulatory changes and co-regulated genes like CIITA.

bioRxiv · Oct 19, 2021Cancer Biology