Author

C. Galicia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

W. Versees· 2 shared A. E. Leschziner· 1 shared A. Pluckthun· 1 shared B. Dreier· 1 shared C. J. Gloeckner· 1 shared D. Chatterjee· 1 shared E. P. Karasmanis· 1 shared F. Preuss· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

W. Versees

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Development of LRRK2 designed ankyrin-repeat proteins

V. Dederer, M. Sanz Murillo, E. P. Karasmanis, K. S. Hatch, D. Chatterjee, F. Preuss, K. R. Abdul Azeez, L. V. Nguyen, C. Galicia, B. Dreier, A. Pluckthun, W. Versees, S. Mathea, A. E. Leschziner, S. L. Reck-Peterson, S. Knapp

This study develops a high-affinity DARPin that binds to LRRK2's WD40 domain, improving structural analysis and revealing its role in disrupting LRRK2 filaments and Rab8A phosphorylation.

bioRxiv · Nov 14, 2023Biochemistry

Structural insights in the GTP-driven monomerization and activation of a bacterial LRRK2 homologue using allosteric nanobodies

C. Galicia, G. Guaitoli, M. Fislage, C. J. Gloeckner, W. Versees

This paper solves the structure of a bacterial Roco protein in its GTP-bound state using cryo-EM and nanobodies, revealing conformational changes and allosteric activation mechanisms.

bioRxiv · Nov 13, 2023 · PreprintBiochemistry

MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus

J. Cherfils, C. Galicia, S. Lhospice, P. Fernandez Varela, S. Trapani, W. Zhang, J. Navaza, T. Mignot

This study identifies MglA's two GTP-bound states and their roles in controlling movement reversals in Myxococcus xanthus.

bioRxiv · Mar 14, 2019Microbiology