Author

B. Dreier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Plueckthun· 3 shared A. Pluckthun· 2 shared J. V. Schaefer· 2 shared S. Furler· 2 shared A. E. Leschziner· 1 shared A. Vieille· 1 shared A.-N. Bondar· 1 shared B. Khanppnavar· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBiochemistry

A. Plueckthun

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Development of LRRK2 designed ankyrin-repeat proteins

V. Dederer, M. Sanz Murillo, E. P. Karasmanis, K. S. Hatch, D. Chatterjee, F. Preuss, K. R. Abdul Azeez, L. V. Nguyen, C. Galicia, B. Dreier, A. Pluckthun, W. Versees, S. Mathea, A. E. Leschziner, S. L. Reck-Peterson, S. Knapp

This study develops a high-affinity DARPin that binds to LRRK2's WD40 domain, improving structural analysis and revealing its role in disrupting LRRK2 filaments and Rab8A phosphorylation.

bioRxiv · Nov 14, 2023Biochemistry

Designed Ankyrin Repeat Proteins for detecting prostate-specific antigen expression in vivo

M. Gut, B. Dreier, S. Furler, J. Sobek, A. Plueckthun, J. P. Holland

This paper develops PSA-specific DARPins for in vivo imaging to monitor drug resistance in prostate cancer.

bioRxiv · Jan 24, 2023 · PreprintBiochemistry

Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system

M. Blanc, C. Lettl, J. Guerin, A. Vieille, S. Furler, S. Briand-Schumacher, B. Dreier, C. Berge, A. Pluckthun, S. Vadon-Le Goff, R. Fronzes, P. Rousselle, W. Fischer, L. TERRADOT

This study characterizes the structure and function of CagI in Helicobacter pylori's type IV secretion system and identifies DARPins that inhibit CagA translocation.

bioRxiv · Nov 8, 2022 · PreprintMicrobiology

Nuclear myosin VI maintains replication fork stability

J. Shi, K. Hauschulte, I. Mikicic, S. Maharjan, V. Arz, J. B. Heidelberger, J. V. Schaefer, B. Dreier, A. Plueckthun, P. Beli, H. D. Ulrich, H.-P. Wollscheid

This study shows that nuclear myosin VI stabilizes stalled or reversed replication forks by interacting with WRNIP1 to prevent DNA2-mediated degradation during replication stress.

bioRxiv · Jul 28, 2022Cell Biology

Structural basis of adenylyl cyclase 9 activation

C. Qi, P. Lavriha, V. Mehta, B. Khanppnavar, I. Mohammed, Y. Li, M. Lazaratos, J. V. Schaefer, B. Dreier, A. Plueckthun, A.-N. Bondar, C. W. Dessauer, V. M. Korkhov

The paper presents cryo-EM structures of AC9 in different states to reveal activator-induced conformational changes essential for its activation.

bioRxiv · Aug 11, 2021Biochemistry