M. Walsh

Crystallographic fragment screen of Enterovirus D68 3C protease and iterative design of lead-like compounds using structure-guided expansions

This study identifies fragments binding to EV-D68 3C protease through crystallography and expands them into lead-like compounds, revealing novel binding modes and structural insights for drug design.

Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals

The paper identifies 75 fragments that bind to Coxsackievirus A16 2A protease, including 38 unique compounds in the active site, offering a path for broad-spectrum anti-enteroviral inhibitors.

High-throughput crystallographic fragment screening of Zika virus NS3 Helicase

This study uses high-throughput crystallographic fragment screening to identify 46 fragment binding poses on ZIKV NS3Hel, providing templates for antiviral drug design.

A scoping review of evidence of naturally occurring Japanese encephalitis infection in vertebrate animals other than humans, ardeid birds and pigs

This review identifies vertebrate animals other than humans, ardeid birds, and pigs with evidence of naturally occurring Japanese encephalitis virus infection, highlighting diagnostic limitations and potential roles in epidemiology.

Comparison of compartmental analytical BOLD fMRI models against Monte Carlo simulations performed over cortical micro-angiograms

The paper compares two BOLD fMRI analytical models against Monte Carlo simulations using mouse cortical micro-angiograms, finding improved accuracy with tridimensional vascular modeling and venous compartment differentiation.

Landscapes associated with Japanese encephalitis virus reflect the functional biogeography of waterbird species across Australia and the Central Indo-Pacific region

The paper examines how waterbird species' functional diversity and traits correlate with Japanese encephalitis virus (JEV) landscape distribution across Australia and the Central Indo-Pacific region.

Structural Analysis of Genomic and Proteomic Signatures Reveal Dynamic Expression of Intrinsically Disordered Regions in Breast Cancer and Tissue

The paper introduces SAGES, a method using structural features to analyze proteomic and transcriptomic data, revealing dynamic expression of intrinsically disordered regions in breast cancer and drug perturbation relationships.

Evolution of Daphnia population dynamics following invasion by a non-native predator

This study examines evolutionary changes in Daphnia population dynamics following invasion by a non-native predator, finding increased population abundance and growth rate in post-invasion populations.

A preliminary description of the ecological characteristics of wild waterbird Japanese encephalitis virus hosts in high risk landscapes in India

This study identifies ecological profiles of Japanese encephalitis virus hosts in high-risk landscapes in India to guide wildlife surveillance.

Low mammalian species richness is associated with Kyasanur Forest disease outbreak risk in deforested landscapes in the Western Ghats, India

The paper assesses the relationship between mammalian species richness and Kyasanur Forest disease (KFDV) outbreak risk in deforested landscapes of the Western Ghats, finding that low species richness is linked to higher outbreak risk in areas with significant forest loss.

12-Lipoxygenase Governs the Innate Immune Pathogenesis of Islet Inflammation and Autoimmune Diabetes

This study shows that 12-LOX promotes islet inflammation and autoimmune diabetes by enhancing macrophage infiltration and migration via CXCR3.

A preliminary ecological profile of Kyasanur Forest disease virus hosts among the mammalian wildlife of the Western Ghats, India

This study identifies ecological traits associated with Kyasanur Forest disease virus hosts in the Western Ghats, finding body mass and forest forage are linked to infection status.

Insights into an alternative pathway for glycerol metabolism in a glycerol kinase deficient Pseudomonas putida KT2440

This study identifies an alternative glycerol metabolism pathway in a glycerol kinase-deficient Pseudomonas putida KT2440 strain, revealing upregulated genes and a new enzymatic function for 3-hydroxybutyrate dehydrogenase.

Ecological and life history traits are associated with Ross River virus infection among sylvatic mammals in Australia

This study identifies ecological and life history traits associated with Ross River virus infection in Australian sylvatic mammals using a piecewise structural equation model.

Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia: A report from the TARGET initiative

The paper identifies genetic mechanisms of primary chemotherapy resistance in pediatric AML through whole-genome and transcriptome sequencing of treatment-failure cases.