Author

A. J. Lewis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:E. coli· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

M. A. Mulvey· 2 shared A. A. Mendez· 1 shared A. Aderem· 1 shared A. Bassett· 1 shared A. C. Richards· 1 shared A. Kaushansky· 1 shared A. N. Douglass· 1 shared A. Tran· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

M. A. Mulvey

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Plant Phenolics Inhibit Focal Adhesion Kinase and Suppress Host Cell Invasion by Uropathogenic Escherichia coli

A. J. Lewis, A. C. Richards, A. A. Mendez, B. K. Dhakal, T. A. Jones, J. L. Sundsbak, D. S. Eto, M. A. Mulvey

The paper tests phenolic compounds for their ability to inhibit uropathogenic Escherichia coli adherence and invasion of bladder cells, finding resveratrol and CAPE significantly reduce host cell entry.

bioRxiv · Nov 23, 2023 · PreprintMicrobiology

Balanced Input from the tRNA Prenyltransferase MiaA Controls the Stress Resistance and Virulence Potential of Extraintestinal Pathogenic Escherichia coli

M. G. Blango, B. A. Fleming, W. M. Kincannon, A. Tran, A. J. Lewis, C. W. Russell, Q. Zhou, L. M. Baird, J. R. Brannon, C. J. Beebout, V. Bandarian, M. Hadjifraniskou, M. T. Howard, M. A. Mulvey

This study shows that MiaA, but not MiaB, is critical for the fitness and virulence of ExPEC, and that stress can alter MiaA expression to affect translation and proteome composition.

bioRxiv · Feb 2, 2021 · PreprintMicrobiology

A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection.

K. Vijayan, N. Arang, L. Wei, R. Morrison, R. Geiger, R. K. Parks, A. J. Lewis, F. D. Mast, A. N. Douglass, H. S. Kain, J. D. Aitchison, J. S. Johnson, A. Aderem, A. Kaushansky

bioRxiv · Aug 31, 2020Cell Biology

A CRISPR Knockout Screen Identifies Foxf1 as a Suppressor of Colorectal Cancer Metastasis That Acts Through Reduced mTOR Signalling

L. Y. Lee, C. Woolley, T. Starkey, L. Freeman-Mills, A. Bassett, F. Franchini, L. M. Wang, A. J. Lewis, R. Arnold, I. Tomlinson

bioRxiv · Apr 18, 2019 · PreprintCancer Biology

Assessing the effect of hypoxia on cardiac metabolism using hyperpolarized 13C magnetic resonance spectroscopy

L. M. Le Page, O. J. Rider, A. J. Lewis, V. Noden, M. Kerr, L. Giles, L. J. A. Ambrose, V. Ball, L. Mansor, L. C. Heather, D. J. Tyler

This study uses hyperpolarized 13C MRS to assess cardiac metabolism under acute and chronic hypoxia in rats, finding altered PDH flux and lactate conversion after 30 minutes and one week of hypoxia.

bioRxiv · Dec 13, 2018Physiology