M. G. Blango

tRNA hypomodification facilitates 5-fluorocytosine resistance via cross-pathway control system activation in Aspergillus fumigatus.

This study shows that tRNA hypomodification in Aspergillus fumigatus leads to 5-fluorocytosine resistance through premature activation of a cross-pathway control system.

RNA-based sensitive fungal pathogen detection

This study demonstrates that detecting fungal rRNA using a minimal input reverse transcription protocol is more sensitive than genomic DNA detection in the presence of human RNA background.

Disruption of the Aspergillus fumigatus RNA interference machinery alters the conidial transcriptome.

This study investigates the role of RNA interference in Aspergillus fumigatus by analyzing genetic variation and functional outcomes of RNAi component knockouts.

PLB-985 neutrophil-like cells as a model to study Aspergillus fumigatus pathogenesis

This paper demonstrates that differentiated PLB-985 cells can model key aspects of A. fumigatus interactions with human neutrophils, including phagocytosis, extracellular trap release, and antifungal vesicle production.

Balanced Input from the tRNA Prenyltransferase MiaA Controls the Stress Resistance and Virulence Potential of Extraintestinal Pathogenic Escherichia coli

This study shows that MiaA, but not MiaB, is critical for the fitness and virulence of ExPEC, and that stress can alter MiaA expression to affect translation and proteome composition.

Biotinylated surfome profiling identifies potential biomarkers for diagnosis and therapy of Aspergillus fumigatus infection

This study identifies 314 surface proteins of Aspergillus fumigatus using biotinylation and LC-MS/MS, proposing them as potential diagnostic and therapeutic targets.

The dynamic surface proteomes of allergenic fungal conidia

This study identifies dynamic surface and secreted proteins of Aspergillus fumigatus conidia under different conditions and compares them to other allergenic molds.

Human neutrophils produce antifungal extracellular vesicles against Aspergillus fumigatus

This study identifies antifungal extracellular vesicles (afEVs) released by human neutrophils in response to Aspergillus fumigatus, which associate with fungal cells and reduce growth through antimicrobial cargo.