Author

C. J. Gaspar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:Drosophila· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

C. Adrain· 2 shared A. Ashkenazi· 1 shared D. Jakubec· 1 shared D. Kan· 1 shared D. Lawrence· 1 shared E. Segal· 1 shared I. Oikonomidi· 1 shared I. Zuazo-Gaztelu· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

C. Adrain

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth

I. Zuazo-Gaztelu, D. Lawrence, I. Oikonomidi, S. Marsters, X. Pechuan-Jorge, C. J. Gaspar, D. Kan, E. Segal, K. Clark, M. Beresini, M.-G. Braun, J. Rudolph, Z. Modrusan, M. Choi, W. Sandoval, , A. Ashkenazi

This study identifies a nonenzymatic role of IRE1 in cancer cell cycle progression and tumor growth, independent of its kinase-RNase activity.

bioRxiv · Nov 22, 2023Cancer Biology

Xport-A functions as a chaperone by stabilizing the first 5 transmembrane domains of Rhodopsin-1

C. J. Gaspar, J. C. Martins, M. N. Melo, T. N. Cordeiro, C. Adrain, P. M. Domingos

The paper proposes a model where Xport-A stabilizes the first 5 transmembrane domains of Rhodopsin-1 during its biosynthesis, acting as a chaperone but not affecting the full-length protein.

bioRxiv · Apr 1, 2022Cell Biology

EMC is required for biogenesis and membrane insertion of Xport-A, an essential chaperone of rhodopsin-1 and the TRP channel

C. J. Gaspar, L. C. Vieira, J. C. Christianson, D. Jakubec, K. Strisovsky, C. Adrain, P. Domingos

The paper identifies Xport-A as an essential chaperone for rhodopsin-1 and TRP channel biogenesis, showing EMC-dependent membrane insertion is required for its function.

bioRxiv · Feb 1, 2021Cell Biology