Author

I. Zuazo-Gaztelu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Ashkenazi· 2 shared A. Alamban· 1 shared C. J. Gaspar· 1 shared D. Kan· 1 shared D. Lawrence· 1 shared E. Segal· 1 shared I. Oikonomidi· 1 shared J. Klumperman· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

A. Ashkenazi

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2 papers

Recent·Most cited

A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth

I. Zuazo-Gaztelu, D. Lawrence, I. Oikonomidi, S. Marsters, X. Pechuan-Jorge, C. J. Gaspar, D. Kan, E. Segal, K. Clark, M. Beresini, M.-G. Braun, J. Rudolph, Z. Modrusan, M. Choi, W. Sandoval, , A. Ashkenazi

This study identifies a nonenzymatic role of IRE1 in cancer cell cycle progression and tumor growth, independent of its kinase-RNase activity.

bioRxiv · Nov 22, 2023Cancer Biology

Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers

V. Belyy, I. Zuazo-Gaztelu, A. Alamban, A. Ashkenazi, P. Walter

This study reveals that IRE1α activation involves reversible dimer-to-oligomer assembly in response to ER stress, with phosphorylation occurring after oligomerization.

bioRxiv · Sep 29, 2021Biophysics